辣椒素改善吞咽功能障碍的研究进展

doi:10.16460/j.issn1008-9969.2022.16.032

摘要/Abstract

摘要： 目的综述辣椒素改善吞咽功能障碍的研究进展,以供临床解决吞咽功能障碍问题提供参考。方法检索国内外数据库,针对辣椒素改善吞咽功能障碍产品来源、剂量剂型、作用机理、应用方式与人群及临床康复效果进行综述。结果辣椒素可通过激活瞬时感受器电位香草酸受体1（TRPV1）触发神经反射机制、痛温觉刺激机制及肌肉收缩机制来改善吞咽功能障碍,促发咳嗽反射,进而预防吸入性肺炎,其在改善各类吞咽障碍方面具有广泛显著的临床效果。不同类型的吞咽功能障碍,辣椒素使用剂量、方式及给药途径不尽相同。结论辣椒素是新兴的可改善吞咽功能障碍的一项康复护理产品,未来研究可着重于制定不同人群使用辣椒素改善吞咽功能障碍的标准化治疗方案,以及研发辣椒素含片、口服液、物化吸入剂等推广至居家和社区的吞咽功能障碍人群。

关键词: 辣椒素, 吞咽功能障碍, 康复护理, 机制研究, TRPV1

中图分类号:

R493

施聪聪, 赵家君, 孙雪峰, 张红石. 辣椒素改善吞咽功能障碍的研究进展[J]. 护理学报, 2022, 29(16): 32-36.

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