以质量求发展，以服务铸品牌

护理学报 ›› 2022, Vol. 29 ›› Issue (16): 37-42.doi: 10.16460/j.issn1008-9969.2022.16.037

• 循证护理 • 上一篇    下一篇

内分泌治疗对乳腺癌患者主客观认知功能影响的系统评价

欧阳蝶, 杨洁, 于相宇, 袁晓玲   

  1. 上海交通大学 护理学院,上海 200025
  • 收稿日期:2022-02-05 出版日期:2022-08-25 发布日期:2022-09-07
  • 通讯作者: 袁晓玲（1983-）,女,上海人,博士,讲师。E-mail:shining_005@126.com
  • 作者简介:欧阳蝶（2000-）,女,四川苍溪人,本科学历,硕士研究生在读。
  • 基金资助:
    上海交通大学护理学院本科毕业设计基金（HLBKBSJJ20-03）

Effects of Endocrine Therapy on Subjective and Objective Cognitive Function in Patients with Breast Cancer: A Systematic Review

OUYANG Die, YANG Jie, YU Xiang-yu, YUAN Xiao-ling   

  1. School of Nursing, Shanghai Jiaotong University, Shanghai 200025, China
  • Received:2022-02-05 Online:2022-08-25 Published:2022-09-07

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摘要： 目的 系统评价内分泌治疗对乳腺癌患者主客观认知功能的影响。方法 计算机检索The Cochrane Library、Medline、Embase、CINAHL、PubMed、Web of Science、中国生物医学文献数据库、万方、维普和中国知网期刊数据库建库至2021年10月31日的文献,根据纳入和排除标进行文献筛选、资料提取和质量评价,最后对纳入的文献进行总结分析。结果 共纳入11篇文献,结果显示,内分泌治疗对乳腺癌患者主客观认知功能影响的评定宜采用联合测试,客观认知表现以记忆力受损最为广泛,主客观认知功能影响的相关性较弱。结论 内分泌治疗对乳腺癌患者认知功能的影响结果尚待进一步统一,提示需关注乳腺癌患者远期认知功能损伤,开展更多高质量研究,进一步验证分析。

关键词: 内分泌治疗, 乳腺癌, 认知功能, 系统评价

Abstract: Objective To systematically review the effects of endocrine therapy on subjective and objective cognitive function in patients with breast cancer. Methods Databases including The Cochrane Library, Medline, Embase, CINAHL, PubMed, Web of Science, SinoMed, Wanfang, VIP and CNKI were searched by computer from the inception to October 31, 2021. Data screening and extraction, quality evaluation, and summary and analysis of the included studies were carried out. Results Eleven studies were connected. Data analysis showed that the effect of endocrine therapy on the subjective and objective cognitive functions of breast cancer patients should be assessed by a combined test. Memory impairment was the most extensive objective cognitive performance, and the correlation between the effects of subjective and objective cognitive functions was weak. Conclusion There is no consensus on the effect of endocrine therapy on cognitive function in breast cancer patients yet, which indicates that more attention should be paid to long-term cognitive function impairment of breast cancer patients. More high-quality studies are needed for further confirmatory analysis.

Key words: endocrine therapy, breast cancer, cognitive function, systematic review

中图分类号: 

  • R473.73
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