Abstract: Objective To To summarize and evaluate the best evidence of the assessment and management of cancer-related cognitive dysfunction (CRCI or CRCD). Methods We searched databases including JBI Evidence-based Health Care International Cooperation Center Library, Cochrane, Up To Date, Web of Science, Embase, PubMed, National Guidelines Database, National Comprehensive Cancer Guidelines Network, Ontario Registered Nurses Association of Canada, Scottish College Guidelines Network, International Guidelines Collaboration Group, British International Institute of Clinical Optimization and other databases and guidelines networks, for evidence related to CRCI evaluation and management. Two researchers conducted independent quality evaluation, evidence extraction and summary of the literature. Results Thirteen articles were found in this study, including 2 guidelines, 2 JBI evidence summaries, and 9 systematic reviews. Twenty-one pieces of best evidence were summarized into two domains: assessment (assessment of related knowledge and assessment tools) and management (non-drug and drug management). Conclusion The evaluation and management of CRCI should be conducted with evidence-based thinking, and the relevant evidence of CRCI should be summarized to guide clinical medical staff to provide relevant guidance on CRCI.

Key words: cancer-related cognitive impairment, CRCI, cancer, assessment of cognitive function, evidence-based thinking