急性白血病患儿住院期间感染性腹泻影响因素病例对照研究

doi:10.16460/j.issn1008-9969.2020.23.053

摘要/Abstract

摘要： 目的探讨急性白血病住院患儿发生感染性腹泻的影响因素。方法回顾性分析2017年7月—2018年7月上海市某三级甲等儿童专科医院内急性白血病患儿的临床资料,根据是否发生感染性腹泻,分为感染性腹泻组(n=48)和非感染性腹泻组(n=1 293),对影响感染性腹泻的相关因素进行二分类Logistic回归分析。结果 1 341例急性白血病住院患儿中有48例发生感染性腹泻,发生率为3.58%。二分类Logistic回归分析结果显示,使用过阿糖胞苷、使用过蒽环类药物、使用过糖皮质激素、有过输血治疗、住院时处于夏季、非固体饮食是急性白血病患儿发生感染性腹泻的危险因素(P<0.05);身高是急性白血病患儿发生感染性腹泻的保护性因素(P<0.05)。结论使用过阿糖胞苷、蒽环类药物、糖皮质激素、有过输血治疗、住院时处于夏季、非固体饮食的急性白血病患儿会增加感染性腹泻发生的风险;身高越高的急性白血病患儿发生感染性腹泻的风险低。应加强早期风险评估、健康宣教、及预防干预措施,以降低高危患儿的感染性腹泻发生率。

关键词: 急性白血病, 感染性腹泻, 保护性因素, 危险因素

Abstract: Objective To explore the risk factors for infectious diarrhea in hospitalized children with acute leukemia.Methods We conducted a retrospective analysis of the data of hospitalized pediatric patients with infectious diarrhea in a specialized pediatric hospital in Shanghai from July 2017 to July 2018,and children were divided into infectious diarrhea group (n=48),and control group without infectious diarrhea(n=1,293).Binary logistic regression analysis was carried out to explore the risk factors of infectious diarrhea.Results There were 48 cases of infectious diarrhea in 1,341 patients with acute leukemia,with an incidence rate of 3.58%.Binary logistic regression analysis showed that anthracyclines,cytarabine,glucocorticoids,blood transfusion,admitting in summer and non-solid food were risk factors of infectious diarrhea in hospitalized children with acute leukemia (P<0.05).And the results also showed that the higher height was the protective factor for infectious diarrhea in leukemia patients(P<0.05).Conclusion Hospitalized pediatric patients with anthracyclines,cytarabine or glucocorticoids or blood transfusion,admitting in summer,or having non-solid food would be at higher risk of infectious diarrhea but those with higher height have the lower risk of infectious diarrhea.Early assessment of risk factors,health instructions,and preventions should be emphasized to decrease the incidences of infectious diarrhea.

Key words: acute leukemia, infectious diarrhea, protective factor, risk factor

中图分类号:

R473.72

陈琳, 葛铮铮, 张晓艳. 急性白血病患儿住院期间感染性腹泻影响因素病例对照研究[J]. 护理学报, 2020, 27(23): 53-57.

CHEN Lin, GE Zheng-zheng, ZHANG Xiao-yan. Case-control Study on Risk Factors of Infectious Diarrhea in Hospitalized Children with Acute Leukemia[J]. Journal of Nursing, 2020, 27(23): 53-57.

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