Abstract:Based on the framework of organizational ambidexterity, this article introduced a new concept, relative Guanxi orientation, to explore the role of managing for ambidexterity of networking and innovation on entrepreneurial growth. Results showed that an inverted U shape between relative Guanxi orientation and new venture growth, which was negatively moderated by the level product and factor development and property protection. It concluded the relative cost and return of implementing the strategic ambidexterity between networking and innovation varies with the development of economic institutions.