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Journal of Nursing ›› 2022, Vol. 29 ›› Issue (20): 1-5.doi: 10.16460/j.issn1008-9969.2022.20.001

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Effect of Frailty on Prognosis in Elderly Patients with Transient Ischemic Attack

DENG Yinga, HUANG Shana, HU Hui-xiub, SUN Chaob   

  1. a.Dept.of Neurosurgery; b.Dept.of Nursing Administration, Beijing Hospital, National Center of Geriatrics, Institute of Geriatrics, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2022-07-21 Published:2022-11-08

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Abstract: Objective To investigate the effect of frailty on the prognosis of elderly patients with transient ischemic attack (TIA) during 2-year follow-up and to analyze the risk factors of prognosis. Methods We conducted a longitudinal cohort study. Elderly patients with TIA who were treated in neurosurgery department of tertiary, grade-A hospital in Beijing from January 2017 to January 2020 were selected. According to whether combined with frailty or not, patients were divided into pre-frailty group (n=102), frailty group (n=47) and control group of 60 cases without frailty. After 24 months of follow-up, the main outcome indicators were the occurrence of cerebrovascular events, including all-cause death and recurrent TIA. Kaplan-meier survival analysis and log-rank test were used to compare the prognosis of the three groups. Cox proportional risk regression model was used to analyze the related factors of cerebrovascular events. Results In 209 patients, b-type natriuretic peptide in pre-frailty group and frailty group was higher than that in the control group (P<0.05). There were 33 cases (15.8%) of cerebrovascular events, including 5 cases (2.4%) of all-cause death and 28 cases (13.4%) of recurrence. Kaplan-meier survival analysis and log-rank test showed that the recurrence or mortality of frailty group was significantly higher than that of the control group (χ2=3.883, P=0.049). Multivariate Cox proportional risk regression model showed that frailty and atrial fibrillation were risk factors of cerebrovascular events. Conclusion Frailty can significantly increase the risk of recurrent TIA in elderly patients with TIA, and is a risk factor associated with cerebrovascular events.

Key words: frailty, transient ischemic attack, elderly, cerebrovascular events, risk factor

CLC Number: 

  • R473
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