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护理学报 ›› 2019, Vol. 26 ›› Issue (15): 70-75.doi: 10.16460/j.issn1008-9969.2019.15.070

• 临床护理 • 上一篇    下一篇

妇科癌症患者癌症相关性认知功能损害的神经心理学研究

张扬a, 罗太珍b, 林燕珊a, 安春燕a, 曾细根a   

  1. 广州医科大学附属第三医院 a.生殖医学中心; b.妇产科研究所,广东 广州 510150
  • 收稿日期:2019-06-09 发布日期:2020-07-08
  • 通讯作者: 罗太珍（1975-）,女,四川合江人,硕士研究生,主任护师。E-mail：928609669@qq.com
  • 作者简介:张扬（1993-）,女,湖北天门人,硕士研究生。
  • 基金资助:
    广东省医学科研基金项目（A2015141）

Neuropsychological Study of Cancer-related Cognitive Impairment in Women with Gynecological Cancer

ZHANG Yanga, LUO Tai-zhenb, LIN Yan-shana, AN Chun-yana, ZENG Xi-gena   

  1. a. Reproductive Medicine Center; b. Gynecology and Obstetrics Research Center, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
  • Received:2019-06-09 Published:2020-07-08

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摘要： 目的 了解妇科癌症患者癌症相关性认知功能损害的神经心理学特点。方法 采用逻辑记忆测试、词语流畅性测试、Stroop 色词干扰测试、连线测试A、医院焦虑抑郁量表、中文版简明疲劳量表,对研究组146例妇科癌症患者、健康对照组112例健康成年女性进行调查,比较2组得分差异性和指标间的相关性。结果 （1）神经心理学测试结果显示,研究组在 Stroop 色词测试文字阅读、颜色阅读中耗时、连线测试 A 中耗时大于健康对照组人群（P<0.05）;研究组在词语流畅性测试、逻辑记忆测试中得分均低于健康对照组人群（P<0.05）;（2）相关性分析结果显示,即时记忆得分、词语流畅性测试总分与抑郁得分呈一定负相关（r=-0.164,-0.214,P<0.05）;Stroop色词干扰测试总耗时、连线测试A耗时与抑郁得分呈一定正相关（r= 0.183,0.275,P<0.05）;词语流畅性测试总分与焦虑得分呈一定负相关（r=-0.267,P<0.05）;连线测试A耗时与焦虑得分呈一定正相关（r=0.196,P<0.05）;Stroop色词干扰测试总耗时、连线测试A与疲劳得分呈一定正相关（r=0.258,0.196,P<0.05）。结论 妇科癌症患者存在不同程度的癌症相关性认知功能损害,主要表现为注意力、记忆力、语言功能和执行功能的改变,且与焦虑、抑郁和疲劳存在一定的相关性。

关键词: 妇科癌症, 患者, 认知功能损害, 癌症相关性, 神经心理学

Abstract: Objective To investigate the neuropsychological characteristics of cancer-related cognitive impairment (CRCI) in women with gynecological cancer. Methods Verbal fluency test (VFT), stroop color words test (SCWT), trail making test A (TMTA), logical memory test (LM), Hospital Anxiety and Depression Scale (HADS), Chinese Version of the Brief Fatigue Inventory (BFI-C) were conducted to investigate 146 patients with gynecologic cancer (study group) and 112 healthy controls (control group). Results (1)Neuropsychological test showed that time-consuming of stroop test A, stroop test B and TMT-A test in study group were longer (P<0.05) but the scores of VFT and logical memory test were lower in study group than those in the control group (P<0.05);(2)Correlation analysis showed that immediate memory and VFT were negatively correlated with depression (r=-0.164, -0.214, P<0.05) but stroop and TMT-A positively with it (r= 0.183, 0.275, P<0.05). VFT was negatively correlated with (r=-0.267, P<0.05) but TMT-A positively with anxiety (r=0.196, P<0.05). Stroop and TMT-A were positively correlated with fatigue (r=0.258, 0.196, P<0.05). Conclusion CRCI exists in gynecological cancer survivors in varying degrees, demonstrated by the change of attention, memory, language and executive function, and there is correlation between CRCI and anxiety, depression and fatigue.

Key words: gynecological cancer, patient, cognitive impairment, cancer-related, neuropsychological characteristics

中图分类号: 

  • R473.71
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