Abstract:Based on the theory of structural contingency, developed a framework of cross-functional dissent-radical innovation, then innovative atmosphere and knowledge exploration are introduced in this study respectively as the moderator and the mediator to address the mechanisms during cross-functional integrated radical innovation process, which is constructed as a mediated moderation model. An empirical research is conducted by using the data collected from 304 manufacturing firms’ in mainland China. This studycombines stepwise hierarchical regression and the Bootstrapping methods to verify the model. The results show that cross-functional dissent is beneficial to radical innovation. Knowledge exploration mediates the relationship between cross-functional dissent and radical innovation. The relationship between cross-functional dissent and knowledge exploration is moderated by innovative atmosphere. Knowledge exploration mediates the positive moderating effect of innovative climate on the relationship between cross-functional dissent and radical innovation.