以质量求发展，以服务铸品牌

护理学报 ›› 2019, Vol. 26 ›› Issue (22): 27-32.doi: 10.16460/j.issn1008-9969.2019.22.027

• 循证护理 • 上一篇    下一篇

低水平激光治疗慢性伤口有效性与安全性的Meta分析

邓波1, 李飞1, 吴秀丽2, 李显蓉2   

  1. 1.西南医科大学 护理学院,四川 泸州646000;
    2.西南医科大学附属医院,四川 泸州 646000
  • 收稿日期:2019-07-22 发布日期:2020-07-27
  • 通讯作者: 李显蓉（1968-）,女,四川泸州人,本科学历,硕士研究生导师,主任护师。E-mail:1204987356@qq.com
  • 作者简介:邓 波（1994-）,男,四川巴中人,本科学历,硕士研究生在读。
  • 基金资助:
    泸州市科技计划项目[2017-S-40（1/18）]

Efficacy and Safety of Low-level Laser Therapy for Chronic Wounds: A Meta-analysis

DENG Bo1, LI Fei1, WU Xiu-li2, LI Xian-rong2   

  1. 1. School of Nursing, Southwest Medical University, Luzhou 646000, China;
    2. Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
  • Received:2019-07-22 Published:2020-07-27

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摘要： 目的 评价低水平激光治疗慢性伤口的有效性和安全性。方法 检索PubMed、Medline、EMbase、Cochrane Library、Web of Science、BMJ Best Practice、CBM、中国知网、万方、维普数据库,并检索伤口治疗相关专业网站,搜集关于低水平激光治疗慢性伤口的随机对照试验,检索时间均从建库至2018年12月,使用Cochrane Review Handbook 5.1.0进行质量评价,采用RevMan 5.3进行Meta分析。结果 共纳入16个随机对照研究,509例患者。结果 显示：低水平激光组未愈合伤口面积[MD=-0.63,95%CI（-0.97,-0.29）,P<0.01]、伤口面积平均减少率[MD=22.17,95%CI（19.34, 25.00）,P<0.01]、伤口治愈人数[OR=2.04,95%CI（1.33,3.12）,P<0.01]、伤口疼痛值[MD=-4.34,95%CI（-4.92,-3.75,P<0.01]与对照组比较差异均有统计学意义,而不良事件发生率[OR=0.66,95%CI（0.24,1.81）,P=0.42]与对照组比较差异无统计学意义。结论 低水平激光能加速伤口愈合,有效减轻伤口治疗期间患者疼痛,并且是安全的。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

关键词: 低水平激光, 下肢静脉溃疡, 糖尿病足, 压力性溃疡, Meta分析

Abstract: Objective To evaluate the efficacy and safety of low-level laser therapy for chronic wounds. Methods Randomized controlled trials (RCTs) of low-level laser therapy for chronic wounds were collected from PubMed, Medline, EMbase, Cochrane Library, Web of Science, BMJ Best Practice, CBM, China Knowledge Network, Wanfang data and VIP data by computer from the inception to December of 2018. The quality of the included studies was evaluated using Cochrane Review Handbook 5.1.0 and performed using RevMan 5.3 software. Results Sixteen RCTs and 509 patients were included in the study. Meta-analysis showed that the area of non-healing wounds in the low-level laser group [MD=-0.63, 95%CI (-0.97, -0.29), P<0.01], mean reduction in wound area [MD=22.17, 95%CI(19.34, 25.00), P<0.01 ], the number of wounds cured [OR=2.04, 95%CI (1.33, 3.12), P=0.01] and the value of wound pain [MD=-4.34, 95%CI (-4.92, -3.75), P<0.01] in the observation group were significantly different from those of the control group, but the incidence of adverse events [OR=0.66,95%CI（0.24, 1.81）, P=0.42] was not statistically significant. Conclusion Low-level laser can accelerate wound healing, effectively alleviate pain during wound treatment, and it is safe. Subject to the limitations of the number and quality of studies included, the above conclusions are yet to be verified by more high-quality studies.

Key words: low-level laser, varicose ulcer, diabetic foot, pressure ulcer, Meta-analysis

中图分类号: 

  • R473.5
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