Comprehensive evaluation indices were carefully selected and constructed to measure the ability of technology development from the perspective of technology commercialization. The quantitative measurement of technical interrelatedness between biotechnology and information technology was realized by adopting these indices. The typical data were sampled from the financial data of the top 10 companies marketed in NASDAQ relative to information and biology technology. The research results show that the interrelatedness between biology technology and the information technology in base and system layer was gradually enhanced in the past ten years, except for the information technology in support layer.