With the rapid development of economic globalization and increasing fierce international competition, there is international trend in transnational corporations' research and development. To solve the issues faced by transnational corporations in choosing the locations of overseas R&D institutions, this paper uses casestudy methods to analyze the process of AVX corporation in its overseas R&D institutions location choices, in addition to the other two cases. It constructs a framework of influencing factors in the choice of transnational corporations' overseas R&D institutions location, the process of which includes three stages  mode determination, macro location choice and micro location choice, under three different investment motivation. In the end, verification analysis is made using cases.