Abstract:This paper put forward a macro management theory of “Big organization” making organization with wisdom, proposed the meaning of Big organization’s wisdom, as well as the pentagon smart structures of Big organization. It includes perspectivetreat organizational behavior with broad vision, conceptunderstand organization with brand new concept, operation mode which is a gravity operation mode generating clustering effect and attracting all excellent resources, platform which is a platform Ecosystem complements core competence of organization with strength from other organizations and creates value together, and theorystart from humanity which strengthens organization itself by means of caring.