Abstract: Objective To summarize the nursing experience of an infant with severe meconium aspiration syndrome (MAS) treated with extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) and nitric oxide (NO). Methods For the infant with MAS, the focus and difficulty of nursing in the process of treatment included the following aspects: strengthened communication and cooperation in the multidisciplinary medical team; dynamic monitoring of coagulation and rational use of anti-coagulation medication; delicacy fluid management; prevention and treatment of infection and individualized family education. Results After 26 hours of ECMO treatment, the child occurred pulmonary hypertension crisis.NO was inhaled immediately,but it did not work. After the assessment by MDT, given the pipe blockage of ECMO, the ECMO device was replaced immediately with the consent of the family. Because of the concurrent severe systemic leakage syndrome and less urine, bedside CRRT treatment was performed. After 25 days of hospitalization, the infant was recovered and discharged. Conclusion ECMO combined with CRRT and NO therapy plays a crucial role in rescuing the infant with MAS, and the cooperation of MDT and high-quality care is the guarantee of successful treatment.

Key words: meconium aspiration syndrome, extracorporeal membrane oxygenation, continuous renal replacement therapy, nitric oxide, nursing