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Journal of Nursing ›› 2019, Vol. 26 ›› Issue (11): 49-54.doi: 10.16460/j.issn1008-9969.2019.11.049

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Risk Factors of PICC-related Venous Thrombosis in Cancer Patients: A Meta-analysis

TIAN Ting1, HUANG Rui-na1, QI Yi1, ZHOU Ya-juan1, HAN Hui1, LIU Wan-jun1, HE Hai-xia2, WU Xiao-wan1   

  1. 1. School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006;
    2. Dept. of Gynecology, Guangdong Proncivial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China
  • Received:2018-12-10 Published:2020-07-08

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Abstract: Objective To identify the risk factors of PICC-related venous thrombosis in cancer patients through meta analysis and provide reference for the prevention and reduce of PICC-related venous thrombosis. Methods We retrieved CNKI, CBM, Wangfang Datbase, VIP, Baidu Library, PubMed, Embase, Web of Science, Medline, Cochrane from the inception to November 2018 to collect case-control studies and cohort studies on risk factors of PICC-related venous thrombosis in cancer patients. Meta analysis was performed by using Stata 13.0 and the Egger's linear regression to test publication bias. Results There were 18 included articles of 6, 425 patients, 825 in case group/exposed group and 5, 600 in control group/non-case group. Risk factors and OR value were as follows: aged over 60, 2.560 (95%CI：1.653~3.967); overweight or obesity, 3.552 (95%CI：2.103~5.998), combined with hypertension, 2.041 (95%CI：1.302~3.200), combined with diabetes, 2.021 (95%CI：1.695~2.409 ), a history of PICC, 2.188 (95%CI：1.204~3.976), having radiotherapy with PICC, 4.308 (95%CI：1.901~9.763), inadequate activity, 4.559 (95%CI：1.035~20.085), infection, 2.748 (95%CI：1.397~5.408), TNM stage III to IV 2.746 (95%CI：1.643~4.589) and tumor metastasis, 4.023 (95%CI：1.895~8.544). Egger's linear regression showed that publication bias was found pertaining to inadequate activity, tumor metastasis and having radiotherapy with PICC. Conclusion Risk factors of PICC-related venous thrombosis in cancer patients include aged over 60, overweight or obesity, combined with hypertension or diabetes, a history of PICC, infection and TNM stage III to IV but there are not adequate evidences for risk factors such as inadequate activity, tumor metastasis and having radiotherapy with PICC. Early intervention should be performed for changeable risk factors and more monitoring for unchangeable ones.

Key words: cancer, PICC, venous thrombosis, risk factor, Meta analysis

CLC Number: 

  • R472.9
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