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Journal of Nursing ›› 2022, Vol. 29 ›› Issue (16): 37-42.doi: 10.16460/j.issn1008-9969.2022.16.037

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Effects of Endocrine Therapy on Subjective and Objective Cognitive Function in Patients with Breast Cancer: A Systematic Review

OUYANG Die, YANG Jie, YU Xiang-yu, YUAN Xiao-ling   

  1. School of Nursing, Shanghai Jiaotong University, Shanghai 200025, China
  • Received:2022-02-05 Online:2022-08-25 Published:2022-09-07

Abstract: Objective To systematically review the effects of endocrine therapy on subjective and objective cognitive function in patients with breast cancer. Methods Databases including The Cochrane Library, Medline, Embase, CINAHL, PubMed, Web of Science, SinoMed, Wanfang, VIP and CNKI were searched by computer from the inception to October 31, 2021. Data screening and extraction, quality evaluation, and summary and analysis of the included studies were carried out. Results Eleven studies were connected. Data analysis showed that the effect of endocrine therapy on the subjective and objective cognitive functions of breast cancer patients should be assessed by a combined test. Memory impairment was the most extensive objective cognitive performance, and the correlation between the effects of subjective and objective cognitive functions was weak. Conclusion There is no consensus on the effect of endocrine therapy on cognitive function in breast cancer patients yet, which indicates that more attention should be paid to long-term cognitive function impairment of breast cancer patients. More high-quality studies are needed for further confirmatory analysis.

Key words: endocrine therapy, breast cancer, cognitive function, systematic review

CLC Number: 

  • R473.73
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