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Journal of Nursing ›› 2022, Vol. 29 ›› Issue (15): 59-64.doi: 10.16460/j.issn1008-9969.2022.15.059

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Symptom Clusters and Sentinel Symptoms of Children with Acute Lymphoblastic Leukemia during Maintenance Chemotherapy

SHEN Xin-yi1,2a, LI Rong-rong2b, CHAN Yu-ying2c, ZHANG Guan-xun1, YANG Qi2a, ZHANG Lin1   

  1. 1. School of Nursing, Suzhou Medical College of Soochow University, Suzhou 215006, China;
    2a. Dept. of Hematology;2b. Dept. of Nursing Administration;2c. Trade Union, Children's Hospital of Soochow University, Suzhou 215002, China
  • Received:2022-03-21 Online:2022-08-10 Published:2022-09-07

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Abstract: Objective To explore the symptom clusters and their sentinel symptoms in children with acute lymphoblastic leukemia during maintenance chemotherapy. Methods With convenience sampling, children with acute lymphoblastic leukemia who received maintenance chemotherapy in department of hematology of Children's Hospital of Soochow University from June 2020 to August 2021 were selected and assessed by Memorial Symptom Assessment Scale 10-18. The formation of symptom clusters was determined by exploratory factor analysis with Spearman rank correlation analysis, and the sentinel symptoms of clusters were determined by Apriori algorithm association analysis. Results Five symptom clusters in children with acute lymphoblastic leukemia during maintenance chemotherapy were identified, including emotional-psychological cluster, gastrointestinal cluster, somatic cluster, neurosystem cluster, and self-image disorder cluster, and the Cronbach ɑ coefficient was 0.943, 0.906, 0.874, 0.891 and 0.900, respectively; insomnia, vomiting, cough, headache, and hair loss were the sentinel symptoms of the clusters respectively. Conclusion Children with acute lymphoblastic leukemia experience a variety of symptom clusters during maintenance chemotherapy. The identification of symptom clusters and sentinel symptoms is helpful to simplify the evaluation and management of symptoms, improve the efficiency of symptom management, and reduce the disease burden of children and their families.

Key words: acute lymphoblastic leukemia, children, maintenance chemotherapy, symptom clusters, sentinel symptoms

CLC Number: 

  • R473.55
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