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Journal of Nursing ›› 2022, Vol. 29 ›› Issue (10): 54-59.doi: 10.16460/j.issn1008-9969.2022.10.054

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Best Evidence Summary of Prevention and Management of Coagulation during Continuous Renal Replacement Therapy without Heparin

YANG Jian-guo1a, HE Xi-fei1b, YAN Jian-jun1a, ZHANG Zhong-hua1a, TONG hui1a, YANG Chun-zi1c, WANG Yan-fang2   

  1. 1a. Blood Purification Center; 1b. Teaching and Research Office of Internal Medicine; 1c. Dept. of Nursing Administration,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
    2. JBI Evidence-based Nursing Cooperation Center of Nanfang Hospital, Guangzhou 510515, China
  • Received:2021-08-13 Online:2022-05-25 Published:2022-06-09

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Abstract: Objective To summarize the best evidence for the prevention and management of coagulation during continuous renal replacement therapy (CRRT) without heparin, and to provide reference for clinical practice. Methods The questions were identified based on evidence-based nursing, and we searched the guide websites including the JBI international cooperation center database, Guidelines International Network, and Chinese and English databases including CNKI, PubMed, and professional academic websites including the International Society of Nephrology, and the Chinese Medical Association Nephrology Branch to collect clinical practice guidelines, expert consensus, best clinical practice, evidence summaries and systematic reviews related to CRRT. Then evidence was extracted from the eligible literature through quality evaluation. Results Ten articles were collected, including 1 clinical practice guidelines, 2 expert consensuses, 1 evidence synthesis and 6 systematic reviews. Thirty pieces of best evidence from 6 aspects covering risk assessment, vascular access, consumable materials, heparin-free anti-coagulation, parameters setting, and monitoring during treatment were summed up. Conclusion The best evidence provides guidance for clinical practice, helps to reduce the occurrence of coagulation during heparin-free CRRT and provide patients with professional care.

Key words: continuous renal replacement therapy, extracorporeal circulation, coagulation, best evidence, evidence-based nursing

CLC Number: 

  • R459.5
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