以质量求发展，以服务铸品牌

Journal of Nursing ›› 2022, Vol. 29 ›› Issue (8): 40-45.doi: 10.16460/j.issn1008-9969.2022.08.040

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Prevention and Management of Chemotherapy-induced Constipation in Patients with Acute Leukemia: A Evidence-based Nursing Practice Project

YAO jing-jing1, LIU Ying1,2, XU Hui-juan1, SUN Si-min1, CHEN Min1, JIANG Xue-jie1   

  1. 1. Dept. of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;
    2. Nanfang Nursing Centre for Evidence-based Practice: A JBI Centre of Excellence, Guangzhou 510515, China
  • Received:2021-07-27 Online:2022-04-25 Published:2022-05-11

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Abstract: Objective To develop the best prevention and management strategies for chemotherapy-induced constipation (CIC) in patients with malignant tumors, to apply the best evidence in clinical practice to enhance the outcome of CIC in acute leukemia patients based on the clinical characteristics of the patients, individual needs and current medical resources of the hospital. Methods The JBI clinical evidence practice application model was followed, including baseline audit, evidence application practice reform and effect assessment after evidence application. The best evidence was translated into eight review indicators and applied to patients with acute leukemia. The compliance rate of the best evidence by nurses before and after evidence application, the patient's compliance with self-assessment of symptoms, the number of patients defecating 1 week before and 1 week after chemotherapy, as well as the number of Bristol I and II defecation patterns were compared. Results After evidence application, nurses' compliance rates of the precautions and management strategies of CIC were significantly improved (P<0.001); there were no significant differences in the number of defecation and the number of Bristol I and II fecal morphology within 1 week after chemotherapy when compared with that before chemotherapy (P>0.05). Conclusion Best evidence-based strategies for the prevention and management of CIC in patients with acute leukemia can enhance the compliance of nurses with all of the audits and improve defecation after chemotherapy in patients with acute leukemia.

Key words: acute leukemia, chemotherapy, chemotherapy-induced constipation, evidence-based practice

CLC Number: 

  • R473.55
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