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Journal of Nursing ›› 2019, Vol. 26 ›› Issue (23): 6-10.doi: 10.16460/j.issn1008-9969.2019.23.006

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Changes of Symptom Clusters among Nasopharyngeal Carcinoma Patients undergoing Concurrent Chemoradiotherapy: A Longitudinal Study

ZHANG Na1, SONG Jin-xia2, WANG Hong-qiao2, ZHOU Jing2, JIN Yong-long2, WANG Yuan-yuan2, SUN Hui-hui1   

  1. 1. School of Nursing, Qingdao University, Qingdao 266100, China;
    2. Affiliated Hospital, Qingdao University, Qingdao 266003,China
  • Received:2019-07-31 Published:2020-07-27

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Abstract: Objective To explore the types and dynamic changes of symptom clusters in nasopharyngeal carcinoma patients with concurrent chemoradiotherapy during different treatment phases and to provide reference for extended symptom management. Methods With convenient sampling method, 118 nasopharyngeal carcinoma patients with concurrent chemoradiotherapy were recruited. The MDASI- H&N was used to collect the data at the end of 2, 4, 6 weeks after radiotherapy (T1, T2, T3 respectively), and 1 month after radiotherapy (T4). Symptom clusters were constructed using exploratory factor analysis. Results Four symptom clusters were extracted, in which fatigue-sleep-emotion symptom clusters and oral mucosal symptom clusters persisted in T1-T4; vocal-dysphagia symptom clusters in T2-T4, and gastrointestinal symptom clusters only existed in T2-T3. The severity of symptom clusters at different time points was statistically significant（P<0.05）. Conclusion It is necessary to pay more attention to the dynamic changes of symptom clusters in nasopharyngeal carcinoma patients with concurrent chemoradiotherapy and take targeted interventions based on internal symptoms at each time point.

Key words: nasopharyngeal carcinoma, concurrent chemoradiotherapy, symptom clusters, longitudinal study

CLC Number: 

  • R473.76
[1] 中国抗癌协会头颈肿瘤专业委员会. 头颈部肿瘤综合治疗专家共识[J]. 中华耳鼻咽喉头颈外科杂志, 2010, 45(7):535-541.DOI:10.3760/cma.j.issn.1673-0860.2010.07. 003.
[2] 翟莹莹,杨姮,周文琴.癌症患者症状群概述及管理措施研究现状[J].护理学报,2019,26(1):32-35.DOI:10.16460/j.issn1008-9969.2019.01.032.
[3] 陈亚琼,周建荣,杨靖.鼻咽癌患者同步放化疗期间的症状群及影响因素研究[J].重庆医科大学学报,2014,39(12):1830-1834.DOI:10.13406/j.cnki.cyxb.000391.
[4] Xiao W L, Chan C W H, Fan Y, et al. Symptom Clusters in Patients with Nasopharyngeal Carcinoma during Radiotherapy[J]. Eur J Oncol Nurs, 2017, 28:7-13.DOI:10.1016/j.ejon.2017.02.004.
[5] Rosenthal D I, Mendoza T R, Chambers M S, et al.Measuring Head and Neck Cancer Symptom Burden: The Development and Alidation of the M. D. Anderson Symptom Inventory, Head and Neck Module[J]. Head neck, 2007,29(10):923-931. DOI:10.1002/hed.20602.
[6] 曹文婷. TACE肝癌患者症状、症状群及生活质量的纵向研究[D].上海:第二军医大学,2012.DOI:10.7666/d.y2111078.
[7] 沈怡. 鼻咽癌病人同步放化疗期间营养状况调查及其影响因素分析[D].天津:天津医科大学,2017.
[8] 吴彩军,孟志强,刘鲁明.鼻咽癌患者放疗期间症状困扰对生活的影响[J].上海护理,2012,12(1):9-12.DOI:10.3969/j.issn.1009-8399.2012.01.003
[9] Powell C, Schick U, Morden J P, et al.Fatigue during Chemoradiotherapy for Nasopharyngeal Cancer and its Relationship to Radiation Dose Distribution in the Brain[J].Radiother Oncol, 2014, 110(3):416-421. DOI:10.1016/j.radonc. 2013.06. 042.
[10] 谢晓冬,张潇宇.癌因性疲乏最新进展--NCCN(2018版)癌因性疲乏指南解读[J].中国肿瘤临床,2018,45(16):817-820.DOI:10.3969/j.issn.1000-8179.2018.16.676.
[11] 宋旭生,杨艳杰,王文博,等.宫颈癌患者自我效能感与癌因性疲乏的关系:疾病不确定感的中介作用研究[J].哈尔滨医科大学学报,2018,52(2):156-159.
[12] 张丽娟. 吞咽功能训练对放射治疗的头颈部肿瘤患者吞咽困难的干预效果[D].天津:天津医科大学,2016.DOI:10.7666/d.D01140914.
[13] 赖小英. 鼻咽癌治疗对患者睡眠及疲乏的影响[D].南宁:广西医科大学,2018.
[14] 张全志,姚大志,董卫军,等.乳腺癌症状群与生活质量的相关性研究[J].护理研究,2016,30(4A):1167-1170.DOI:10.3969/j.issn.1009-6493.2016.10.006.
[15] Nishiura M, Tamura A, Nagai H, et al.Assessment of Sleep Disturbance in Lung Cancer Patients: Relationship between Sleep Disturbance and Pain, Fatigue, Quality of Life, and Psychological Distress[J]. Palliat Support Care, 2015, 13(3):575-581.DOI:10.1017/s1478951513001119.
[16] Dreidi, Mu'taz M, Hamdan-Mansour A M. Pain, Sleep Disturbance, and Quality of Life Among Palestinian Patients Diagnosed with Cancer[J]. J Cancer Edu, 2016, 31(4):796-803.DOI:10.1007/s13187-015-0946-5.
[17] 邓杨清,王庆兰.运动疗法在癌症患者癌因性疲乏中应用的研究进展[J].护理学报, 2016, 23(15):22-25.DOI:10.16460/j.issn1008-9969.2016.15.022.
[18] 刘鑫,江锦芳,覃彦珠,等.鼻咽癌放化疗患者口腔黏膜炎防护策略的循证实践[J].护理学报,2018,25(11):26-30.DOI:10.16460/j.issn1008-9969.2018.11.026.
[19] Ma L, Wu T, Pan J, et al.The Correlation Between the Comprehensive Nutrition Index and Quality of Life of Patients with Nasopharyngeal Carcinoma Treated by Intensity-modulated Radiotherapy[J]. Nutr Cancer, 2014, 66(1):152-158. DOI:10.1080/01635581.2014.853815.
[20] Steen L V D, Gestel D V, Vanderveken O, et al. Evolution of Self-perceived Swallowing Function, Tongue Strength and Swallow-related Quality of Life during Radiotherapy in Head and Neck Cancer Patients[J]. Head Neck, 2019, 41(3):1-11.DOI:10.1002/hed.25684.
[21] 张丽娟,姜男,赵岳.吞咽功能训练对头颈部肿瘤放射治疗患者吞咽困难的效果[J].中国康复理论与实践,2016,22(3):350-353.DOI:10.3969/j.issn.1006-9771.2016.03. 025.
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