护理学报 ›› 2020, Vol. 27 ›› Issue (6): 23-28.doi: 10.16460/j.issn1008-9969.2020.06.023
冷冻疗法降低化疗患者口腔黏膜炎发生的Meta分析
裴露斯, 杨雪梅, 翟田田, 赵亚芸, 冯兰棱, 张迁
- 兰州大学护理学院,甘肃 兰州 730030
摘要： 目的 通过Meta分析评价冷冻疗法降低化疗患者口腔黏膜炎发生率的效果。方法 检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Web of Science、The Cochrane Library、EMbase、Medline数据库,获取冷冻疗法作为干预措施对化疗患者口腔黏膜炎实施的随机对照试验,检索时限为建库至2019年6月,分别由2名研究人员独立根据纳排标准进行筛选文献,采用RevMan5.3软件进行Meta分析。结果 共纳入10篇随机对照试验,761例患者。Meta分析结果显示,与对照组相比,试验组冷冻疗法能有效地降低化疗引起的口腔黏膜炎发生率[RR=0.62,95%CI（0.53,0.72）,P<0.01],减轻口腔黏膜炎严重程度[RR=0.37,95%CI（0.27,0.51）,P<0.01],缓解疼痛以及减少止痛剂的使用[RR=0.13,95%CI（0.03,0.52）,P<0.01]。在减少全肠外营养支持的需要上差异无统计学意义（P=0.23）。结论 冷冻疗法可以明显降低化疗引起的口腔黏膜炎发生率,减轻口腔黏膜炎严重程度,缓解疼痛以及减少止痛剂的使用,但在减少全肠外营养支持的需要方面缺乏证据支持,需要高质量的研究进行验证。
中图分类号:
- R473.73
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