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Journal of Nursing ›› 2021, Vol. 28 ›› Issue (11): 1-6.doi: 10.16460/j.issn1008-9969.2021.11.001

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Meta-analysis of Risk Factors for Frailty in Diabetic Patients

NIU Xiao-dan, ZHANG Jing, GUO Jing-bo, RUAN Hai-hui, CHI Jun-ting, TAO Hong-xia, WANG Yan-hong   

  1. School of Nursing, Lanzhou University, Lanzhou 730000, China
  • Received:2021-04-11 Online:2021-06-10 Published:2021-07-06

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Abstract: Objective To explore the risk factors of frailty in diabetic patients by meta-analysis and to provide reference for its prevention and treatment. Methods We retrieved China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), Chinese Biomedical Literature Data- base (CBM), Wanfang Database, PubMed, Web of Science, and Cochrane Library from the inception to March 2021 to collect studies on factors associated with frailty in patients with diabetes. Two researchers independently screened the literature, extracted the data and evaluated the risk of bias of the included studies. A meta-analysis on the included literature was performed by using RevMan 5.3. Results Totally 21 articles with 6,937 diabetic patients were included, including 14 cross-sectional studies, 4 cohort studies, and 3 case-control studies. There were 1,562 patients with frailty (22.5%), involving 13 influencing factors. Meta-analysis showed that risk factors of diabetic patients were advanced age (OR=1.29, 95%CI:1.12~1.49), female (OR=2.68, 95%CI:1.88~3.81), less educated (OR=2.30, 95%CI:1.55~3.42), high glycosylated hemoglobin level (OR=1.92, 95%CI: 1.33~2.77), combined other diseases (OR=2.35, 95%CI:1.49~3.73), more hospitalizations (OR=7.28, 95%CI:3.56~14.89), poor nutritional status（OR=3.13, 95%CI：1.96~4.99）, lower activities of daily living（OR=2.74, 95%CI:1.98~3.80） and depression (OR=1.78, 95%CI:1.32~2.41). Weight (OR=1.48, 95%CI:0.30~7.42) and alcohol consumption (OR=2.12, 95%CI:0.67~6.76) were not associated with frailty in diabetic patients. Exercise (OR=0.85, 95%CI:0.74~0.97) and 25 (OH) D3 (OR=0.94, 95%CI:0.90~0.98) were protective factor for frailty in diabetic patients. Sensitivity analysis and publication bias test indicated that there was no publication bias for case-control studies and the results of the meta-analysis were stable. Conclusion The occurrence of frailty in diabetic patients is related to various risk factors, and factors with risk intensity ranging from high to low are more hospitalizations, poor nutritional status, lower activities of daily living, female, combined other diseases, less educated, higher glycosylated hemoglobin level, depression,and advanced age.

Key words: diabetes mellitus, frailty, risk factor, Meta-analysis

CLC Number: 

  • R473.58
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