Abstract: Objective To clarify the risk factors of surgical incision infection in patients with colorectal cancer through meta-analysis, and to provide reference for preventive measures. Methods Case-control studies and cohort studies on risk factors of surgical incision infection in patients with colorectal cancer were searched in databases including CNKI, China Biomedical Literature Database, Wanfang Database, Weipu Database, The Cochrane Library, PubMed, Embase, and Web of Science. Two researchers screened the literature according to the inclusion and exclusion criteria, and evaluated the quality of the included literature by Newcastle-Ottawa Scale(NOS). RevMan5.3 was used to perform statistical analysis. Results Seventeen articles were finally included, with a total of 16,992 cases of colon cancer, and 8 risk factors. Meta-analysis showed that diabetes (OR=1.65, 95%CI: 1.48~1.84), operation time (OR=1.41, 95%CI: 1.22~1.63), BMI (OR=1.35, 95%CI: 1.18~1.55), open surgery (OR=1.60, 95%CI: 1.23~2.07), surgical method (OR=1.69, 95%CI: 1.38~2.08), tumor stage (OR=1.42, 95%CI: 1.28~1.58) , and age (OR=1.28, 95%CI: 1.12~1.47) were risk factors for surgical incision infection in patients with colorectal cancer. Sensitivity analysis and publication bias results show that the combined results of all factors were relatively stable, and no obvious publication bias was found. Conclusion Effective management for basic disease, operation time, weight, open surgery, operation method, tumor stage and age can effectively reduce the incidence of surgical incision infection.

Key words: colorectal cancer, surgical incision, infection, Meta-analysis