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Journal of Nursing ›› 2019, Vol. 26 ›› Issue (22): 27-32.doi: 10.16460/j.issn1008-9969.2019.22.027

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Efficacy and Safety of Low-level Laser Therapy for Chronic Wounds: A Meta-analysis

DENG Bo1, LI Fei1, WU Xiu-li2, LI Xian-rong2   

  1. 1. School of Nursing, Southwest Medical University, Luzhou 646000, China;
    2. Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
  • Received:2019-07-22 Published:2020-07-27

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Abstract: Objective To evaluate the efficacy and safety of low-level laser therapy for chronic wounds. Methods Randomized controlled trials (RCTs) of low-level laser therapy for chronic wounds were collected from PubMed, Medline, EMbase, Cochrane Library, Web of Science, BMJ Best Practice, CBM, China Knowledge Network, Wanfang data and VIP data by computer from the inception to December of 2018. The quality of the included studies was evaluated using Cochrane Review Handbook 5.1.0 and performed using RevMan 5.3 software. Results Sixteen RCTs and 509 patients were included in the study. Meta-analysis showed that the area of non-healing wounds in the low-level laser group [MD=-0.63, 95%CI (-0.97, -0.29), P<0.01], mean reduction in wound area [MD=22.17, 95%CI(19.34, 25.00), P<0.01 ], the number of wounds cured [OR=2.04, 95%CI (1.33, 3.12), P=0.01] and the value of wound pain [MD=-4.34, 95%CI (-4.92, -3.75), P<0.01] in the observation group were significantly different from those of the control group, but the incidence of adverse events [OR=0.66,95%CI（0.24, 1.81）, P=0.42] was not statistically significant. Conclusion Low-level laser can accelerate wound healing, effectively alleviate pain during wound treatment, and it is safe. Subject to the limitations of the number and quality of studies included, the above conclusions are yet to be verified by more high-quality studies.

Key words: low-level laser, varicose ulcer, diabetic foot, pressure ulcer, Meta-analysis

CLC Number: 

  • R473.5
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