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Journal of Nursing ›› 2021, Vol. 28 ›› Issue (3): 46-52.doi: 10.16460/j.issn1008-9969.2021.03.046

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Best Evidence Summary for Prevention of Hemorrhagic Transformation after Thrombolysis in Patients with Acute Ischemic Stroke

WANG Ya-ling, WANG Bing-han, ZHANG Yan, YIN Xue, JIANG Xin, XIONG Xiao-ming, LI Hua-li   

  1. Dept. of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China
  • Received:2020-11-07 Published:2021-03-12

Abstract: Objective To summarize the best evidence for the prevention of hemorrhagic transformation after thrombolysis in patients with acute ischemic stroke and to provide reference for nursing staff to reduce the incidence of hemorrhagic transformation after thrombolysis of stroke. Methods We searched Cochrane Library, JBI, BMJ, PubMed, UpToDate, NGC, GIN, SIGN, NZGG, NICE, RNAO, CNKI, Vip Datebase, Wanfang Datebase, CBM and AHA/ASA, ESO and Canadian Stroke Best Practices for eligible literature. Two researchers independently appraised articles, and extracted data from eligible studies. Results Seventeen articles were enrolled, including 9 guidelines, 5 systematic reviews, 3 expert consensuses/position statement. Totally 26 items of best evidence were summarized from seven aspects:risk factors, condition monitoring, blood pressure management, symptom identification, symptomatic treatment, medication management and diet management. Conclusion Evidence-based standardized prevention strategy should be adopted for the prevention of hemorrhagic transformation after thrombolysis of acute ischemic stroke. It is necessary to select evidence according to the national conditions, clinical practice and patients' wishes. When applying evidence, the best evidence should be applied to the prevention and management of haemorrhage transformation after thrombolysis of acute ischemic stroke, so as to reduce the incidence of hemorrhagic transformation, promote the continuous improvement of nursing quality, the clinical outcome of patients and the satisfaction of patients.

Key words: acute ischemic stroke, thrombolysis, hemorrhagic transformation, symptomatic intracerebral hemorrhage, evidence-based nursing

CLC Number: 

  • R473.74
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