护理学报 ›› 2018, Vol. 25 ›› Issue (20): 24-30.doi: 10.16460/j.issn1008-9969.2018.20.024
赵诗雨, 柯卉, 李梦圆, 熊璨, 喻姣花
ZHAO Shi-yu, KE Hui, LI Meng-yuan, XIONG Can, YU Jiao-hua
摘要: 目的 系统评价肠内营养补充剂预防和治疗压疮的临床效果。方法 计算机检索中国知网、万方数据库、中国科技期刊数据库、Cochrane library、EMbase、Web of Science、PubMed中相关的随机对照试验,检索时间均为建库至2018年3月。对文献质量进行严格评价和资料提取后,应用RevMan 5.3软件进行统计学处理。结果 共纳入20篇随机对照试验研究。Meta分析结果显示:肠内营养补充剂降低了压疮发生率[RR=0.81,95%CI(0.71,0.91),P=0.0008]、提高了压疮治愈率[RR=1.53,95%CI(1.28,1.83),P<0.00001]、加快了压疮面积的缩小[SMD=-1.11,95%CI(-1.39,-0.82),P<0.00001],并且不增加患者的不良反应发生率[RR=0.78,95%CI(0.37,1.63),P=0.51],但不能加快压疮愈合计分的降低[MD=-0.68,95%CI(-1.47, 0.1),P=0.09]。结论 肠内营养补充剂在降低压疮发生率、提高压疮治愈率和加快压疮面积缩小方面具有优越性,具不会增加不良反应的发生率,但其在促进压疮愈合计分的下降、缩短压疮愈合时间方面的效果还不能确定,还需高质量、大样本的随机对照试验予以进一步验证。
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