This paper proposes the end-to-end paradigm as a new organizational management paradigm driven by artificial intelligence. It aims to address the challenges posed by current AI technologies to the traditional division-of-labor paradigm and promote a deep restructuring of the subjects, units, and operational mechanisms of organizations. Through theoretical construction, this paper introduces the hybrid agent as a new type of actor in the human-machine integrated model, replacing positions with tasks to enable dynamic adjustments of organizational units, and thereby drives the deep integration of management and business activities. Based on this, six core propositions are put forward. Furthermore, by incorporating the practical case of CooCaa Technology Co., Ltd, this paper elaborates on the implementation path and results of this paradigm in real organizational contexts. The findings demonstrate that the end-to-end paradigm is not a marginal improvement of existing organizational theories, but a systematic reconstruction of the fundamental assumptions and core logic of management science, providing a new theoretical perspective for understanding the evolution of organizational forms in the age of AI.