以质量求发展，以服务铸品牌

Journal of Nursing ›› 2020, Vol. 27 ›› Issue (17): 67-72.doi: 10.16460/j.issn1008-9969.2020.17.067

Previous Articles     Next Articles

Consistency of Self-report and Nursing Records of Adverse Reactions in Children with Leukemia: A 60-case Study

YANG Bei-bei1,2, TONG Xin-yang1, CHEN Fang2, WANG Xiao-mei2, LI Ling2, LI Li-yan2, WAN Feng-jing1   

  1. 1. School of International Nursing, Hainan Medical University, Haikou 571199, China;
    2. Hainan General Hospital,Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China
  • Received:2020-03-17 Online:2020-09-10 Published:2020-10-15

PDF (PC)

424

Like

Abstract: Objective To investigate the self-report and nursing records of adverse reactions after the initial induction of chemotherapy intrathecal injections in children with acute lymphoblastic leukemia and to compare the consistency of two types of evaluations.Methods With convenience sampling method, 60 acute lymphocytic leukemia children having adjuvant intrathecal injection for the first time from May 2018 to July 2019 in pediatric intensive care units of a tertiary grade-A hospital of Hainan province were selected and investigated using the self-reporting questionnaire on adverse reactions in children after intrauterine injection after twice of intrauterine injections. Children’s self-reported adverse reactions were compared with electronic nursing record of adverse reactions after intra-injection.Results After the first intrasheath injection, there was a statistical difference in the incidence of adverse reactions in 9 of the 12 adverse reactions reported by the children and nursing records(P<0.05), which were nausea, vomiting, constipation, loss of appetite, fatigue, limb numbness, lumbago, dizziness and headache, respectively. Among the severity of adverse reactions, the difference of “fatigue” in the children’s self-report and nursing records was statistically significant (P<0.05), and the consistency of nausea, appetite loss, fatigue, limb numbness, lumbago and dizziness was poor (Kappa<0.4). After the second intrasheath injection, the incidence of adverse reactions was statistically different in 10 of the 12 adverse reactions reported by children and nursing records (P<0.05), which were nausea, vomiting, loss of appetite, taste disorders, diarrhea, fatigue, limb numbness, lumbago, dizziness and headache, respectively. Among the severity of adverse reactions, there was no statistically significant difference between the children’s self-report and nursing records (P>0.05), but the consistency of nausea, vomiting, loss of appetite, taste disorder, diarrhea, fatigue, limb numbness, lumbago and dizziness was poor (Kappa<0.4).Conclusion The incidence and severity of adverse reactions induced by intrathecal injection of chemotherapy in children with acute lymphoblastic leukemia are underestimated and neglected by nurses. Nurses should pay more attention to the self-report of adverse reactions of children, so as to evaluate the adverse reactions of chemotherapy more accurately and improve the quality of care.

Key words: leukemia, intrathecal injection, children self-report, nursing record

CLC Number: 

  • R47
[1] 曹毛毛,陈万青.中国恶性肿瘤流行情况及防控现状[J].中国肿瘤临床,2019, 46(3):145-149.DOI:10.3969/j.issn.1000-8179.2019.03.246.
[2] 郑荣寿,孙可欣,张思维,等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志,2019,41(1):19-28. DOI:10.3760/cma.j.issn.0253-3766.2019.01.008.
[3] Benoit Y, Suciu S, Cave H, et al.The EORTC Children’s Leukemia Group:Preclinical and Clinical Research and Resulting Achievements[J]. Ejc Suppl, 2012,10(1):39-45. DOI: 10.1016/S1359-6349(12)70009-5.
[4] 崔焱. 儿科护理学[M].6版.北京:人民卫生出版社,2017:539-541.
[5] Pui C, Howard SC.Current Management and Challenges of Malignant Disease in the CNS in Paediatric Leukaemia[J]. Lancet Oncol, 2008,9(3):257-268.DOI:10.1016/S1470-2045(08)70070-6.
[6] Mitri Z, Siddiqui MT, Rassi FE,et al.Sensitivity and Specificity of Cerebrospinal Fluid flow Cytometry for the Diagnosis of Leukemic Meningitis in Acute Lymphoblastic Leukemia/Lymphoma[J]. Leukemia Lymphoma, 2014, 55(7):1498-1500.DOI:10.3109/10428194.2013.852667.
[7] 于意. 肿瘤化疗药物应用中不良反应的临床研究[J].中国医药指南,2018,16(10):72-73.DOI:10.15912/j.cnki.gocm.2018.10.051.
[8] Department of Health and Human Services FDA Center for Drug Evaluation and Research. Guidance for Industry: Patient-reported Measures:Use in Medical Product Development to Support Labeling Claims: Draft Guidance[J]. Health Qual Life Out, 2006,4(79):1-20.DOI:10.1186/1477-7525-4-79.
[9] 刘砚燕,陈如男,姚静静,等.患者报告结局的国内外研究进展[J].现代预防医学,2013,40(12):2268-2271.
[10] 刘砚燕. 儿童自我报告结局测量信息系统在儿童癌症人群中的测评[D].上海:第二军医大学,2013.
[11] 吴冰,张柳柳,邾萍,等.乳腺癌患者对化疗不良反应的自我报告与护理记录的一致性研究[J].中华护理杂志,2019,54(2):165-169.DOI:10.3761/j.issn.0254-1769.2019.02.001.
[12] Quinten C, Maringwa J, Gotay C, et al.Patient Self-Reports of Symptoms and Clinician Ratings as Predictors of Overall Cancer Survival[J].JNCI, 2011,103(24):1851-1858. DOI:10.1093/jnci/djr485.
[13] Trotti A, Colevas AD, Setser A, et al.Patient-reported Outcomes and the Evolution of Adverse Event Reporting in Oncology[J]. J Clin Oncol, 2007, 25(32):5121-5127. DOI: 10.1200/JCO.2007.12.4784.
[14] Atherton PJ, Sloan JA.Rising Importance of Patient-reported Outcomes[J]. Lancet Oncol, 2006, 7(11):883-884. DOI:10.1016/S1470-2045(06)70914-7.
[15] 江载芳,申昆玲,沈颖.诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:2351-2375.
[16] 中华人民共和国国家卫生健康委.儿童急性淋巴细胞白血病诊疗规范(2018版)[EB/OL].[2018-10-16][2020-03-10]. http://www.nhc.gov.cn/.
[17] Brown PA, Inaba H, Annesley C, et al.Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology[J]. J Natl Compr Canc Ne, 2020, 18(1):81-112. DOI:10.6004/jnccn.2020.0001.
[18] National Cancer Institute.Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0[EB/OL].[2017-11-27][2019-11-07].https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf.
[19] Irwin DE, Stucky BD, Thissen D, et al.Sampling Plan and Patient Characteristics of the PROMIS Pediatrics Large-scale Survey[J]. Qual Life Res, 2010, 19(4):585-594.
[20] 仇丽霞. 医学统计学[M]. 北京:中国协和医科大学出版社,2018:10-20.
[21] 石义红,粱婧,张蜜香.腹部损伤患者护理评估常见问题及护理对策[J].实用临床医药杂志,2016,20(12):73-75.DOI:10.7619/jcmp.201612023
[22] 陈娟. 癌性疲劳患者化疗前后疲劳评分比较和影响因素分析[D]. 乌鲁木齐:新疆医科大学,2014.
[23] Sheri EF, Carla DeMuro, Lori DM, et al. US FDA Patient-reported Outcome Guidance: Great Expectations and Unintended Consequences[J]. Literature Review.2013, 13(4):441-446.DOI:10.1586/14737167.2013.814957.
[24] Lifland B, Mangionesmith R, Palermo T M, et al.Agreement Between Parent Proxy Report and Child Self-report of Pain Intensity and Health-related Quality of Life after Surgery[J]. Acad Pediatr, 2017, 18(4):376-383. DOI:10.1016/j.acap.2017.12.001.
[25] 任艳霞,宋小秀,张鑫.心理护理干预对小儿白血病患者情绪及细胞因子的影响[J].国际精神病学杂志,2019,46(5):941-943.
[1] WANG Jie, GUO Yan. Development and Test of Questionnaire of Care Knowledge-attitude-practice of Caregivers for Children with Acute Leukemia [J]. Journal of Nursing, 2019, 26(6): 1-5.
[2] WU Yan,GAO Wei,LI Man,ZHOU Xin-yu,SONG Huan-huan,YANG Pu-rui. Qualitative Research on Experience of Caregivers of Leukemia Children [J]. Journal of Nursing, 2017, 24(12): 5-9.
[3] WANG Chun-li,WU Xin-yi,HUO Ling-wei,LI Hui-jun,LIANG Rui. ReIationship among QuaIify of Life, Coping StyIe and ParentaI Rearing of AdoIescent Leukemia Patients [J]. Journal of Nursing, 2015, (7): 56-60.
[4] YU Fang-fang,FU Ju-fang,BAI Yan-ni,HE Hua,ZHU Li,REN Guo-hua,WANG Li-hong. Quality of Life of Acute Leukemia Inpatients and Its Influencing Factors [J]. Journal of Nursing, 2013, (19): 16-19.
Viewed
Full text


Abstract

Cited
  Shared   
No Suggested Reading articles found!