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Journal of Nursing ›› 2023, Vol. 30 ›› Issue (11): 59-64.doi: 10.16460/j.issn1008-9969.2023.11.059

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Predictive power comparison of three different risk assessment models for symptomatic peripherally inserted central catheter related venous thromboembolism among patients with acute myeloblastic leukemia

XU Hui-juan, LIU Ying, YAO Jia-li, YAO Jing-jing, CHEN Min, QIU Tian-tian, XU Dan   

  1. Dept. of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2022-07-29 Online:2023-06-10 Published:2023-07-10

Abstract: Objective To compare the predictive power of the Padua, Caprini and Autar scale for venous thromboembolism associated with symptomatic peripherally inserted central catheter (PICC) in patients with acute myeloid leukemia. Methods From March 2019 to March 2021, 265 patients with acute myeloid leukemia with PICC at the Hematology Department of Nanfang Hospital of Southern Medical University were selected using convenient sampling. The General Information Questionnaire, the Padua scale, the Caprini scale, the Autar scale, and the PICC Maintenance Follow-up Tables were used to collect data. The area under the receiver operating characteristic curve (ROC) of the three scales was calculated and pairwise comparison was performed. The best cut-off value, sensitivities, specificity, and Youden exponents of the scales were calculated. Results Of the 265 patients with acute myeloid leukemia, 37 had symptomatic PICC-associated thrombosis, with an incidence of approximate 14.0%;the median interval between PICC insertion and thrombotic episode was the 19.00th (9.00,61.00) day. The area under the ROC curve of Padua scale, Caprini scale and Autar scale was 0.784, 0.633 and 0.648, respectively, and the area under the ROC curve of Padua scale was significantly higher than that of the other two scales (P<0.05). The sensitivity, specificity, and Youden index of the Padua scale were 0.757, 0.680, and 0.437, respectively, with an optimal cutoff of 4. The sensitivity, specificity, and Youden index of the Caprini scale were 0.676, 0.548, and 0.224, respectively, with an optimal cutoff of 8. The sensitivity, specificity, and Youden index of the Autar scale were 0.595, 0.693, and 0.288, respectively, with an optimal cutoff of 10. Conclusion Compared to the Caprini and Autar scale, the Padua scale provides better prediction for the risk of symptomatic PICC-associated thrombosis in patients with acute myeloid leukemia. However, it is still necessary to develop specific catheter-associated thrombosis risk assessment tools for specific disease groups in the future to improve prediction accuracy.

Key words: acute myeloid leukemia, symptomatic PICC-related venous thromboembolism, Padua scale, Caprini scale, Autar scale

CLC Number: 

  • R473.55
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