HeXie Theme is one of the core concepts in HeXie Management Theory that are proposed to deal with new demands in modern organizational management consisting of complexity, systematicness and fast change. This paper theoretically extends the extant research on HeXie Theme in probing into how organizations can holistically deal with the fast changes in complex environment. Specifically, this paper first conducts indepth analyses on the essential attributes of HeXie Theme, and concludes that HeXie Theme is essentially manifested as a kind of “sense” that leaders make of uncertain organizational context. Then this paper systematically explores the functional characteristics of HeXie Theme by comparing it with other organizational elements, and proposes that HeXie Theme is an effective tool for holistically dealing with fast changes in complex organizational environment. Finally, this paper investigates the identification and representation of HeXie Theme by referring to knowledgebased theory, and reveals the intrinsic mechanism of these two processes. This paper enriches studies in strategic management field on the one hand, and on the other hand, it also sheds light on managerial practice in new economic era.