Innovation network-oriented, by united considering the technologically cooperative innovation mode for the interenterprises and the “Industry-University-Institute”, the dynamic game model with the mode selection among the enterprise technology alliance and one kind of “Industry-University-Institute” cooperative innovation is established. Depending on some equilibrium parameters such as the input scale, input proportion among innovators, product price and innovation profits, the resource-sharing condition for inter-enterprises or enterprise-high college aiming at making cooperative innovation was explored. The effective selection between the two modes, namely technologylicensing mode and the joint ventures one for the integrated innovation mode with the “Industry-University-Institute” was researched. The evolution process and the condition from the enterprise research joint venture mode to the integrated innovation mode with the “Industry-University-Institute” were also explored. Among the most of the theoretical explorations having been researched concerning the cooperative innovation modes, the inter-enterprises and the “Industry-University-Institute” cooperative innovation mode is divided in order to explain the mechanism with each other. The kinds and the effective selection the “Industry-University-Institute” cooperative innovation mode were also studied.