Abstract Using the samples of 175 mobile knowledge workers from 30 Chinese firms, this study used Hierarchical Multiple Regression (HLM) model to empirically test the mediation effect of perceived organizational support between the relationship of High Performance Work System (HPWS) and work alienation, and the moderation effect of mobile time on the relationship of perceived organizational support and work alienation. This study reached two conclusions that: first, HPWS has a significant effect on reducing mobile knowledge workers’ work alienation through perceived organizational support; second, the longer the mobile time is, the less the negative relationship between perceived organizational support and work alienation is. The managerial implication was discussed, accordingly.
2017, Vol. 14 
