In this study, we put learning factors into the microscopic mechanism of business incubator and venture capital's resource sharing decisions in collaborative knowledge creation. After that, we set up a multi-stage and master-slave game model of business incubator and venture capital, then we analyze some factors such as learning factors, taxes strength, financial return and venture capital equity to investigate how to maintain business incubator and venture capital's collaborative knowledge cooperation (information). At the same time, the optimal participation of business incubator and the optimal total investment are analyzed. It is found that business incubator cooperates with venture capital under the condition that business incubator has a higher proportion of income than venture capital, which is obtained from the venture project after collaborative knowledge(information) creation. When the business incubator and venture capital meet the conditions for cooperation, the optimal investment participation of incubator is positively correlated with the strength of government tax and the proportion of financial return, and negatively correlated with the share of venture capital in the venture project. The total investment level of business incubator and venture capital is positively correlated with taxes strength, and the proportion of financial return and the initial learning factor is negatively correlated with the share of venture capital in the venture project, game stage length and market interest rates.