The panelbased unit test and cointegration test demonstrate that throughout the nation, the East, the Central, the Northeast and the West there exists a cointegration relationship between the four abovementioned variables which are all proved as oneorder cointegration ones. Furthermore, the cointegration equation discloses the facts as follows: first, the Northeast achieves the highest contribution rate of industrial structure change related to reduction of unit GDP energy consumption while the East and the Central are at the lowest level, and the effect of the West is positive; second, as for the technical progress effect on unit GDP energy consumption decline, the East stands in the breach, with the West and the Northeast in the wake of it; third, the West ranks number one followed by the East and the Northeast in terms of the contribution rate of openingup degree as to unit GDP energy consumption reduction, and the effect of the Central is positive. In addition, the error correction model indicates that the Northeast has the strongest capability of adjusting itself into balanced state. In strict accordance with the empirical consequence, it is advisable to implement tailored policies and measures for regions with different characteristics when we decide on energy conservation objective in the twelfth "Fiveyear Plans".