The contemporary organizational environment is characterized by 4 key salient components, which are complexity, change, ambiguity, and uncertainty (UACC). Managers are challenged by problems of determining causality, managing holistically, and adaptation to rapid change. Western philosophical approaches to confronting management challenges arising from UACC, inherent in the wider economic environment, emphasize standardization and rational design on the basis of science, law, and religion. Conversely, Oriental philosophical approaches to management challenges oppose such rigid systems in favor of flexibility and adaptability which emphasize harmony and morality. By integrating these two complementary approaches, we propose He Xie Management Theory (HXMT), which establishes a clear vision and mission to direct the development of organizations, organize an integrated management system and cope with management challenges.