On the basis of summarizing the ascertained model of vehicle routing problem with pickups and deliveries and the model of nested sequence policy,two kinds of pickup and delivery systems under the one-to-many logistic network were considered,and cost optimization models for nested sequence policy were set up respectively.According to the data of delivery of beer and collection of beer bottles in one beer factory,a positive analysis was carried out.Through the sensitive analysis of different factors,some laws of logistic costs of pickup and delivery system were revealed.