Based on the open innovation situation, enterprises can realize value chain resource integration across technology boundaries and organizational boundaries. This research explores the relationship among innovation partner heterogeneity (on organizational type, technological ability and target), network relation and open innovation performance, and the relationship is empirically validated by 284 valid questionnaires. The empirical results show that innovation partner heterogeneity and technological ability heterogeneity have an inverted U-shaped relationship with open innovation performance. Target heterogeneity has a negative effect on innovation performance. Moreover, network relation plays an intermediary role in the relationship between innovation partner heterogeneity and innovation performance.